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Research Scientist

Montpellier, France - A4C-RS
Founded in 2023, Arthritis4Cure is a precision immunology company developing first-inclass targeted therapies with curative potential for B- and T- cell-mediated autoimmune diseases, initially focused on rheumatoid arthritis. Our approach is to selectively eliminate pathogenic B- and T- cell clones driving disease progression while preserving healthy immune function. By combining cutting-edge immunology, translational science, and clinical innovation, we aim to deliver durable remission and redefine what is possible for patients living with rheumatoid arthritis and other severe autoimmune diseases.

This is an exciting opportunity for a highly skilled and motivated Research Scientist to join Arthritis4Cure Immunology Team. 
This is an exciting opportunity for a highly skilled and motivated Research Scientist to join Arthritis4Cure Immunology Team. This hands-on role focuses on executing pre-clinical pharmacological studies to evaluate therapeutic candidates for autoimmune diseases. Working under the supervision of the Immunology Department Head, the ideal candidate possesses deep expertise in designing, running, and analyzing in vitro and in vivo mouse models of autoimmunity. 

Main conditions
  • Location: Euromedecine incubator, Montpellier, France 
  • Contracttype: permanent, full time, on site.
 
  • In vivo pharmacology and model development: 
    • o Design, optimize, and execute in vivo efficacy and pharmacokinetic/pharmacodynamic (PK/PD) studies 
    • o Administrate experimental therapeutics via multiple routes (IV, SC, …)
    •  o Perform daily tracking, body weight measurements, and disease-specific clinical scoring (e.g., joint swelling)
    •  o Execute survival blood sampling and terminal tissue harvesting (spleen, lymph nodes, bone marrow, brain/spinal cord) 

  • Ex Vivo & Mechanistic Immunology:
    • o Tissue Processing: Harvest and process primary lymphoid tissues, blood, tissues samples, PBMCs 
    • o Flow Cytometry: Design multi-color (10+ colors) flow cytometry panels to immunophenotype B cells, T cells, myeloid cells, and dendritic cells 
    • o In Vitro Assays: Conduct cell purification, mixed lymphocyte reactions (MLR), B and T cell activation, and suppression assays o Molecular Analytics: Quantify cytokines, chemokines, and autoantibodies via ELISA, ELISpot, MSD, Luminex, or Western Blotting

  • Laboratory, Compliance & Documentation:
    • o Actively participate in the management of the laboratory 
    • o Analyze complex biological data using Prism, FlowJo, or similar analytics software 
    • o Present study findings to cross-functional project teams o Write and maintain protocols, ensuring the highest standards of animal welfare 
    • Maintain meticulous, real-time records in Electronic Lab Notebooks (ELN) to support patent filings 
  • Education: Ph.D. in Immunology, Pharmacology, or a related biological science (or Master's degree with 3+ years of industry experience) 

  • Experience: 0–3 years of postdoctoral or minimum 3+ years of post-Master biotechnology/pharmaceutical industry experience with a strong publication record in immunology 

  • Certifications: Active certification for animal handling is highly preferred 

  • Technical Mastery: Proven hands-on expertise with mouse models of autoimmunity and advanced multi-color flow cytometry 

  • Soft skills: 
    • o Proven experience in working in small team
    • o Scientifically rigourous, excellent project management, collaborative mindset, and experienced in Lab Management 
    • o Fluency in English both orally and in writing, native or able to understand French language, strong written and verbal communication skills 
    • o Autonomous and highly-organized with strong commitment, adaptability and ability to work under time pressure
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